I'm surprised at all the Cangel hate. I can definitely see how many people could think that they were better off as friends, but all in all Cangel was rather inoffensive. I knew a lot of people didn't like it, but I didn't know so many people disliked it.
As for me, I'm torn between Spuffy and Briley.
Spuffy (IMO) ruined Spike's character, was creepy and disturbing in S6, dull in S7, and in the last two seasons consisted of two people that I previously liked but then hated with a fiery passion. But they had one or two good scenes, and the actors did have some chemistry.
Briley was utterly devoid of anything remotely resembling chemistry, was death-defyingly boring, and contained one character I liked and one character I hate more than anyone else. It was far too normal for my liking, and at times it seemed like Riley was emotionally manipulating Buffy. But I found that I could ignore it easily enough by just zoning out, while Spuffy annnoyed/disgusted me too much to ignore it.
I don't like Bangel either, but I can't bring myself to hate them. It did create some great storylines (the S2 Angelus arc), and their romantic moments are just so lol-worthy. 😀
Oh and Connor/Cordelia too, but that didn't last too long so I can ignore it easily enough.
Willow/Xander was chemistryless, but never annoyed me.