I think so. My boyfriend and I have more differences than similarities.
He has completely different political views to me, which has lead to arguments.
He has completely different film/music taste to me.
He's very musical and rhythmic, my old piano teacher once asked me if I was dyslexic, due to my lack of rhythm and ability.
He's shy and quiet, and doesn't like nightclubs, I'm pretty shy at first, but after that I can be annoyingly loud, and love going out.
He cares a lot about what people think of him, for example we spent the day together once and he bought a joint of ham and put it in my fridge. When it came to him taking it home (about a 2 minute walk away) despite it being wrapped in plastic, he wouldn't take it unless it was covered in a bag, because someone might see and think he's weird. I personally couldn't care less (Weird example, sorry).