Going up to the space station or moon is one thing. I would definitely consider it.
Untethering from earth to go into deeper space - or even mars is a whole different business, IMO. Without near light speed travel and a much more robust space travel infrastructure, the answer would be no.
The isolation, more than the danger, would get me.
Closer in, I would do anything that was as safe as the space shuttle - preferably a little safer, since we did lose two. Driving down the road or flying has risk. Yet we do it. Hell, riding a horse is potentially life-threatening! So considering that... Looking down on earth from the shuttle or moon has definite appeal.